103585-88-2

Upstream product

• 110-62-3 pentanal 
• 3524-20-7 5-amino-1-pentylpyrazole 
• 89158-72-5 [[(1-n-pentyl-5-pyrazolyl)amino]methylene]malonic acid diethyl ester 
• 89158-74-7 4-Chloro-1-n-pentyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 89158-73-6 4-Hydroxy-1-n-pentyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 89158-20-3 3-[N'-Pent-(E)-ylidene-hydrazino]-propionitrile 
• 89865-57-6 4-amino-1-n-pentyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents

A series of 1-substituted 4-amino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid esters and amides were synthesized and screened for anxiolytic activity in the shock-induced suppression of drinking (SSD) test. The compounds were also tested for their ability to displace [3H]flunitrazepam (FLU) from brain benzodiazepine (BZ) binding sites. Many compounds were active in these screens and, additionally, demonstrated a selectivity for the type 1 BZ (BZ1) receptor over the type 2 BZ (BZ2) receptor as indicated by Hill coefficients significantly less than unity and analysis of [3H]FLU binding results from different brain regions. Based on the results of structure-activity studies of these compounds, a hypothesis was proposed to explain the structural features necessary for optimal interaction with brain BZ receptors. A detailed pharmacological evaluation of one of the most potent behaviorally active compounds (27) demonstrated it to be BZ1 selective; also, in comparison to diazepam, 27 showed minimal sedative and alcohol interactive properties at therapeutically effective doses.