1035912-41-4

Upstream product

• 503821-94-1 2-iodo-3-bromobenzoic acid 
• 526-75-0 2,3-Dimethylphenol 
• 37621-79-7 sodium 2,3-xylenolate 

Downstream Products

• 117570-53-3 vadimezan 
• 129095-08-5 5,6-dimethylxanthenone-4-acetic acid sodium salt 

Relevant academic research and scientific papers

PREPARATION OF 5,6-DIMETHYLXANTHONE-4-ACETIC ACID, THE DERIVATIVES PREPARED AND PHARMACEUTICAL FORMULATIONS THEREOF

The invention provides a method for preparing 5,6-dimethylxanthone-4-acetic acid (DMXAA) and its derivatives. The derivatives are represented by formula (I), wherein R is defined as the description. The invention also provides the pharmaceutical formulations containing such derivatives useful as excellent antitumor and antibacterial agents.

5,6-DIMETHYL XANTHONE-4-ACETIC ACID DERIVATIVES AND METHOD OF PREPARING THE SAME

A method of preparation of 5,6-dimethylxanthone-4-acetic acid (DMXAA) and derivatives thereof. The derivatives are represented by formula (I), wherein R represents totally 1 to 2 substitutes at 1, 2, 3, 7, and 8 position selected from a lower alkyl, halogen, CF3, CN, NO2, NH2, CH2COOH, OR2, OH, NHSO2R2, SR2, CH2CONHR2 or NHR2, and R2 represents a lower alkyl, or a lower alkyl having OH, NH2, or OCH3. The invention further provides a pharmaceutical composition having such derivatives used as excellent antitumor and antibacterial agents.