103594-83-8

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 88045-77-6 1-(benzyloxy)methyl-5-chloro-2(1H)-pyrimidinone 
• 16635-23-7 phenyltriisopropoxytitanium(IV) 
• 103594-75-8 1-benzyloxymethyl-5-chloro-3,4-dihydro-4-phenylpyrimidin-2(1H)-one 

Relevant academic research and scientific papers

Aryl- and Alkynyltri-isopropoxytitanium Reagents in Regioselective Carbon-Carbon Bond Formation in Azines

Regioselective arylation in the 4-position in pyridines results from 1:1-adduct formation between an aryltriisopropoxytitanium reagent and N-isobutyloxycarbonyl- or an N-silyloxymethyl-3-cyanopyridinium salt after successive DDQ dehydrogenation and cleavage of the 1-substituent.Complete regioselectivity for new C-C bond formation in the 4-position results in the adduct formation between aryl- and phenylethynyltri-isopropoxytitanium reagents and pyrimidin-2(1H)-ones; with ethynyltriisopropoxytitanium the new C-C bond formation occurs at the 6-position.

Regioselectivity in the Reactions of Aryltri-isopropoxytitanium with Pyrimidinones.

Complete regioselectivity is observed in the 1:1-adduct formation between aryltri-isopropoxytitanium reagents and pyrimidin-2(1H)ones: the new carbon-carbon-bond is formed at C-4.Dehydrogenation gives the arylated, fully conjugated heterocycle.