103597-08-6

Upstream product

• 108-24-7 acetic anhydride 
• 91363-90-5 ((3aR,5S,6R,6aR)-6-azido-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate 
• 94795-72-9 1,2-O-isopropylidene-5-O-benzoyl-3-O-trifluoromethanesulfonyl-α-D-xylofuranose 
• 532-20-7 D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 

Downstream Products

• 103597-09-7 9-(3'-azido-2'-O-acetyl-5'-O-benzoyl-3'-deoxy-β-D-ribofuranosyl)-N⁶-benzoyladenine 
• 215176-58-2 1-(3'-azido-3'-deoxy-β-D-ribofuranosyl)thymine 
• 1519007-46-5 3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-5-methyluridine 
• 215176-57-1 3'-azido-2'-O-acetyl-5'-O-benzoyl-3'-deoxy-5-methyluridine 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of 3'-deoxy-3'-(4-substituted-triazol-1-YL)-5- methyluridine

An efficient protocol has been developed for the synthesis of a small library of 3'-deoxy-3'- (4-substituted-triazol-1-yl)-5-methyluridine using Cu(I)-catalyzed Huisgen-Sharpless-Meldal 1,3- dipolar cycloaddition reaction of 3'-azido-3'-deoxy-5-methyluridine with different alkynes under optimized condition in an overall yields of 76%-92%. Here, the azido precursor compound, i.e., 3'-azido-3'-deoxy-5-methyluridine was chemoenzymatically synthesized from D-xylose in good yield. Some of the alkynes used in cycloaddition reaction were synthesized by the reaction of hydroxycoumarins or naphthols with propargyl bromide in acetone using K2CO3 in excellent yields. All synthesized compounds were unambiguously identified on the basis of their spectral (IR, 1H-, 13C NMR spectra, and high-resolution mass spectra) data analysis.

Synthesis and antiviral evaluation of AZT analogues with a spacer arm between glucidic and base moieties. Part II

This article describes the synthesis of a series of AZT analogues bearing an acyclic chain between the sugar and the base moieties is described. These new compounds were readily obtained using microwave irradiation. The compounds were characterized by 1H