1036-36-8Relevant academic research and scientific papers
Compounds with NS3 serine proteinase inhibitory activity and application thereof
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Paragraph 0063; 0068; 0069; 0070; 0071; 0072; 0074, (2017/11/18)
The invention specifically relates to compounds with NS3 serine proteinase inhibitory activity and application thereof, belonging to the field of chemical pharmacy. The invention discloses the compounds with NS3 serine proteinase inhibitory activity or pharmaceutically acceptable salts, mesomers, racemates, enantiomers, diastereomers or mixtures thereof. The structure of the compounds is as shown in the general formula (I) which is described in the specification; and the compounds comprise compounds as shown in a general formula (II) which is described in the specification, or compounds as shown in a general formula (III) which is described in the specification, or pharmaceutically acceptable salts, mesomers, racemates, enantiomers, diastereomers or mixtures thereof. Results of antiviral activity tests show that the compounds have good NS3 serine protease inhibitory activity, have the potential of being developed into novel NS3 serine protease inhibitors, and can be applied to preparation of drugs for preventing, handling and treating flavivirus infective diseases caused by hepatitis C viruses, Dengue viruses and/or West Nile viruses.
