1036027-60-7

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoroMethyl)-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoroMethyl)-;1-(p-tolylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyrrolo[2,3-b]pyridine;1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1h-
• CAS NO: 1036027-60-7
• Molecular Formula: C₂₁H₂₂BF₃N₂O₄S
• Molecular Weight: 466.2815896
• Mol File: 1036027-60-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoroMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoroMethyl)-(1036027-60-7)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoroMethyl)-(1036027-60-7)

Safety Data

• Hazardous Substances Data: 1036027-60-7(Hazardous Substances Data)

Usage

Molecular Structure

1H-Pyrrolo[2,3-b]pyridine core with a trifluoromethyl group at the 5-position, a dioxaborolane group at the 3-position, a sulfonyl group at the 1-position, and a 4-methylphenyl group attached to the sulfonyl group.

Functional Groups

Trifluoromethyl (CF3), sulfonyl, dioxaborolane, and 4-methylphenyl groups.

Potential Applications

Organic synthesis, pharmaceuticals, and materials science.

Trifluoromethyl (CF3)

Can improve pharmacokinetic properties, metabolic stability, and lipophilicity of molecules.

Sulfonyl

Can enhance molecular stability and act as a leaving group in certain reactions.

Dioxaborolane

Boron-containing moiety that can participate in various chemical reactions, such as Suzuki-Miyaura cross-coupling.

4-Methylphenyl

Can influence the electronic properties and steric hindrance of the molecule.

Upstream product

• 1036027-58-3 3-bromo-5-trifluoromethyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1036027-62-9 2-(methylthio)-4-(1-tosyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidine-5-carbonitrile 
• 1036028-05-3 2-(5-cyano-4-(1-tosyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)2-methyl-N-(2,2,2-trifluoroethyl)propanamide 
• 1422052-42-3 ethyl 2-(1-tert-butyl-2-(5-fluoro-2-(1-tosyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)hydrazinyl)ethanoate 

Relevant articles and documents

INHIBITORS OF INFLUENZA VIRUSES REPLICATION

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.