1036030-20-2Relevant academic research and scientific papers
Scalable synthesis and isolation of the four stereoisomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate, useful intermediates for the synthesis of S1P1 receptor agonists
Wallace, Grier A.,Gordon, Thomas D.,Hayes, Martin E.,Konopacki, Donald B.,Fix-Stenzel, Shannon R.,Zhang, Xiaolei,Grongsaard, Pintipa,Cusack, Kevin P.,Schaffter, Lisa M.,Henry, Rodger F.,Stoffel, Robert H.
experimental part, p. 4886 - 4889 (2009/10/02)
(Chemical Equation Presented) The individual isomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate are useful intermediates for the synthesis of S1P1 receptor agonists. Herein we describe a scalable synthesis and isolation of each of the four stereoisomers of this compound in gram quantities with >98% ee and de. The utility of this approach is demonstrated by the synthesis of ((1R,3R)-1-amino-3-(4-octylphenyl)cyclopentyl)methanol in 7 steps, 11% overall yield, and >98% ee and de.
PROCESS FOR THE PREPARATION AND ISOLATION OF THE INDIVIDUAL STEREOISOMERS OF 1-AMINO, 3-SUBSTITUTED PHENYLCYCLOPENTANE CARBOXYLATES
-
Page/Page column 19-20, (2008/12/07)
The present invention discloses processes for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates.
SPHINGOSINE-1 -PHOSPHATE RECEPTOR AGONIST AND ANTAGONIST COMPOUNDS
-
Page/Page column 47; 56-57, (2008/12/07)
The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.
