1036030-35-9

Upstream product

• 1036030-15-5 (7S)-7-(4-bromophenyl)-1,3-diazaspiro[4.4]nonane-2,4-dione 
• 160678-59-1 (S)-3-(4-bromophenyl)cyclopentanone 
• 5467-74-3 4-Bromophenylboronic acid 
• 930-30-3 cyclopent-2-enone 

Downstream Products

• 1036030-37-1 (1R,3S)-methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate 
• 1036030-21-3 methyl (1R,3S)-amino-3-(4-bromophenyl)cyclopentane-1-carboxylate hydrochloride 
• 1622180-53-3 (5R,7S)-7-(4-bromophenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one 
• 1240554-98-6 ((1R,3S)-1-amino-3-(4-bromophenyl)cyclopentyl)methanol 
• 1622180-56-6 tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate 
• 1622180-57-7 2-(4-((SR,7S)-2-oxo-3-oxa-1-azaspiro [4,4]nonan-7-yl)phenyl)acetic acid 
• 1622180-31-7 ((1R,3S)-1-amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol 
• 1036030-36-0 (3S)-methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLIC COMPOUNDS

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V) and/or a salt thereof, wherein R1 is OH or OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

BICYCLIC COMPOUNDS

Disclosed are compounds of Formula (I) and/or a salt thereof; wherein R is —OH or —OP(O)(OH)2. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.