1036204-97-3Relevant academic research and scientific papers
Design, synthesis and SAR of novel glucokinase activators
Cheruvallath, Zacharia S.,Gwaltney II, Stephen L.,Sabat, Mark,Tang, Mingnam,Feng, Jun,Wang, Haixia,Miura, Joanne,Guntupalli, Prasuna,Jennings, Andy,Hosfield, David,Lee, Bumsup,Wu, Yiqin
, p. 2166 - 2171 (2013/05/09)
Guided by co-crystal structures of compounds 15, 22 and 30, an SBDD approach led to the discovery of the 6-methyl pyridone series as a novel class of GKAs that potently activate GK in enzyme and cell assays. Anti-diabetic OGTT efficacy was demonstrated with 54 in a mouse model of type 2 diabetes.
