103624-50-6

Basic information

• Product Name: {[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]methyl}benzene
• Synonyms: {[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]methyl}benzene
• CAS NO: 103624-50-6
• Molecular Weight: 240.677
• Mol File: 103624-50-6.mol

Chemical Properties

• CAS DataBase Reference: {[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]methyl}benzene(CAS DataBase Reference)
• NIST Chemistry Reference: {[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]methyl}benzene(103624-50-6)
• EPA Substance Registry System: {[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]methyl}benzene(103624-50-6)

Safety Data

• Hazardous Substances Data: 103624-50-6(Hazardous Substances Data)

Upstream product

• 77745-03-0 2,2,2-trifluoroethylthiomethylbenzene 
• 151-67-7 1,1,1-trifluoro-2-bromo-2-chloroethane 
• 100-53-8 phenylmethanethiol 

Downstream Products

• 103624-51-7 4-(1,1-dichloro2,2,2-trifluoro-ethylthio)methylbenzene 

Relevant articles and documents

A facile synthesis of 1-chloro-2,2,2-trifluoroethyl sulfides

A facile synthesis of structurally diverse 1-chloro-2,2,2-trifluoroethyl sulfides from readily available 1-bromo-1-chloro-2,2,2-trifluoroethane (Halothane) and various aliphatic and aromatic thiols in the presence of sodium dithionite/sodium bicarbonate is described. The synthetic utility of the prepared sulfides is illustrated by the synthesis of biologically potent heterocycles and by their electrophilic reactions with thiophene.

Chemoselective reaction of a sulfonate ester with methoxide ions in preference to benzyl mercaptide anions

Trifluoroethyl benzyl sulfide was prepared (in 2-propanol) and subsequently chlorinated as a further test of substituent electronegativity based regiochemical predictions.The initial attempt to prepare that sulfide by reaction of 2,2,2-trifluoroethyl methanesulfonate and benzyl mercaptide anions (in methanol) furnished benzyl methyl sulfide.Mechanistic possibilities are discussed in detail and some synthetic consequences of this novel reaction are presented.

CHLOR-TRIFLUORMETHYL-SULFIN, CF3ClC=SO

Chloro-trifluoromethylsulfine (6) could be synthesized by two methods.The two isomers observed are of of unexpected different stability at room temperature.