1036243-86-3Relevant academic research and scientific papers
A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors
Wang, Tiansheng,Ledeboer, Mark W.,Duffy, John P.,Pierce, Albert C.,Zuccola, Harmon J.,Block, Eric,Shlyakter, Dina,Hogan, James K.,Bennani, Youssef L.
scheme or table, p. 153 - 156 (2010/04/02)
Pictet-Spengler condensation of aldehydes or alpha-keto-esters with 4-(2-anilinophenyl)-7-azaindole (11) or deazapurine (12) gave high yields of the 3,4-fused cyclic compounds. SAR studies, by varying the substituted benzaldehyde components, lead to the discovery of a series of potent JAK2 kinase inhibitors.
TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE
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Page/Page column 35, (2010/04/25)
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in
