1036244-45-7Relevant academic research and scientific papers
One-pot preparation of Julia-Kocienski sulfides and sulfones from alcohols
Ando, Kaori,Hattori, Junichiro
, (2019/08/12)
A method for one-pot preparation of Julia-Kocienski sulfides and sulfones from alcohols and thiols is reported. A variety of primary alcohols were converted to the corresponding mesylates by methansulfonyl chloride and triethylamine in THF. After the reaction is complete, thiol (1 or 10) and either NaH or t-BuOK were added. The Julia-Kocienski sulfides 3, 9 and 11 were prepared by one-pot two steps procedure from alcohols in 76–96% yields (16 examples). Furthermore, after the sulfide formation, the reaction mixture was neutralized by p-toluenesulfonic acid and treated with H2O2 and ammonium molybdate in EtOH to give the Julia-Kocienski sulfones 4 in good yields except for trans-2-hexen-1-ol.
Total synthesis of artochamins F, H, I, and J through cascade reactions
Nicolaou,Lister, Troy,Denton, Ross M.,Gelin, Christine F.
, p. 4736 - 4757 (2008/09/21)
A concise and efficient cascade-based total synthesis of artochamins F, H, I, and J is described. The potential biogenetic connection between artochamin F, or a derivative thereof, and artochamins H, I, and J, through an unusual formal [2+2] cycloaddition
Cascade reactions involving formal [2+2] thermal cycloadditions: Total synthesis of artochamins F, H, I, and J
Nicolaou,Lister, Troy,Denton, Ross M.,Gelin, Christine F.
, p. 7501 - 7505 (2008/09/17)
(Chemical Equation Presented) State of the artochamins: Total syntheses of artochamins F (1), H (2), I (3), and J (4; see scheme) have been achieved through a flexible and expedient strategy that features a cascade sequence involving two concurrent [3,3]
