1036260-45-3

Basic information

• Product Name: trans-3-Aminocyclobutanol
• Synonyms: trans-3-Aminocyclobutanol
• CAS NO: 1036260-45-3
• Molecular Formula: C₄H₉NO
• Molecular Weight: 87.12036
• Mol File: 1036260-45-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 157.6°C at 760 mmHg
• Flash Point: 49.1°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 0.977mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: 2-8°C(protect from light)
• PKA: 15.00±0.40(Predicted)
• CAS DataBase Reference: trans-3-Aminocyclobutanol(CAS DataBase Reference)
• NIST Chemistry Reference: trans-3-Aminocyclobutanol(1036260-45-3)
• EPA Substance Registry System: trans-3-Aminocyclobutanol(1036260-45-3)

Safety Data

• Hazardous Substances Data: 1036260-45-3(Hazardous Substances Data)

Usage

General Description

Trans-3-Aminocyclobutanol is a cyclic chemical compound that contains an amino group attached to a four-membered cyclobutane ring. It is often used in organic synthesis and chemical research due to its unique properties. This chemical is typically found as a clear, colorless liquid, although its exact appearance may depend on the specific method of preparation or storage. Its properties such as boiling point, melting point, density, and flash point may differ depending on the conditions. Being an amine, it may engage in typical amine reactions including condensation, alkylation, and acylation. Handling this compound requires safety precautions due to potential health risks.

InChI:InChI=1/C4H9NO/c5-3-1-4(6)2-3/h3-4,6H,1-2,5H2/t3-,4-

Upstream product

• 937376-04-0 C₁₉H₂₁NO₃ 

Downstream Products

• 389890-42-0 tert-butyl N-[(1r,3r)-3-hydroxycyclobutyl]carbamate 
• 1443749-26-5 C₄₁H₄₂Cl₂FN₃O₄ 

Relevant articles and documents

Synthesis method of trans-3-aminobutanol

The invention discloses a method for synthesizing trans-3-aminobutanol, belongs to the field of organic chemical synthesis, and provides a novel method for synthesizing trans-3-aminobutanol in order to solve the problems of low safety, low yield, difficulty in obtaining a high-purity product and the like of an existing route. The method specifically comprises the following reaction steps: (1) carrying out mitsunobu reaction on a compound as shown in a formula II and carboxylic acid substances under the action of a condensing agent, and salifying to generate a compound as shown in a formula III; 2) hydrolyzing the compound shown in the formula III under an alkaline condition to obtain a compound shown in a formula IV; and 3) removing benzyl from the compound in the formula IV under the action of a catalyst to obtain the compound in the formula I. According to the invention, the method for synthesizing trans-3-aminobutanol is novel in process route, the total molar yield is greater than 70%, and the method has the characteristics of short route, high chemical purity and easiness in production.