1036355-80-2Relevant academic research and scientific papers
Formyl group activation of a bromopyrrole ester in Suzuki cross-coupling reactions: Application to a formal synthesis of Polycitone A and B and Polycitrin A
Gupton, John T.,Telang, Nakul,Wormald, Michael,Lescalleet, Kristin,Patteson, Jon,Curry, Will,Harrison, Andrew,Hoerrner, Megan,Sobieski, John,Kimmel, Michael,Kluball, Emily,Perry, Thomas
, p. 2738 - 2745 (2014/04/17)
A new pyrrole building block is described, which allows for the regiospecific synthesis of 2,3,5-trisubstituted pyrroles and 2,3,4,5-tetrasubstituted pyrroles. Optimization studies are presented for the preparation of the pyrrole building block along with the evaluation of various cross-coupling conditions and cross-coupling agents. A short, formal synthesis of the natural products Polycitone A, Polycitone B, and Polycitrin A from the pyrrole building block is also described.
