1036374-96-5Relevant articles and documents
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)- pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate
Anselm, Lilli,Banner, David W.,Benz, J?rg,Groebke Zbinden, Katrin,Himber, Jacques,Hilpert, Hans,Huber, Walter,Kuhn, Bernd,Mary, Jean-Luc,Otteneder, Michael B.,Panday, Narendra,Ricklin, Fabienne,Stahl, Martin,Thomi, Stefan,Haap, Wolfgang
scheme or table, p. 5313 - 5319 (2010/10/21)
A series of (3R,4R)-pyrrolidine-3,4-dicarboxylic acid amides was investigated with respect to their factor Xa inhibitory activity, selectivity, pharmacokinetic properties, and ex vivo antithrombotic activity. The clinical candidate from this series, R1663
PROCESSES FOR THE PREPARATION OF (3R, 4R) -N- (4 -CHLOROPHENYL) -1- (2, 2-DIFLUOROETHYL) -N' - [2-FLUORO-4- (2-OXO-1 (2H) -PYRIDINYL) PHENYL] -3, 4-PYRROLIDINEDICARBOXAMIDE
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Page/Page column 45, (2008/12/06)
The invention is concerned with processes for the manufacture of pyrrolidine-3,4- dicarboxamide derivative of formula (I), and the intermediates useful for those processes.