1036389-09-9

Basic information

• Product Name: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-
• Synonyms: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-;6-Amino-4-fluoro-2,3-dihydro-1H-isoindol-1-one;6-Amino-4-fluoroisoindolin-1-one;6-Amino-4-fluoro-2,3-dihydroisoindol-1-one
• CAS NO: 1036389-09-9
• Molecular Formula: C₈H₇FN₂O
• Molecular Weight: 166.1523832
• Mol File: 1036389-09-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-(1036389-09-9)
• EPA Substance Registry System: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-(1036389-09-9)

Safety Data

• Hazardous Substances Data: 1036389-09-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1H-Isoindol-1-one, 6-amino-4-fluoro-2,3-dihydrois used as a chemical intermediate for the synthesis of various organic compounds and materials. Its unique structure and functional groups make it a promising candidate for the development of new drugs and therapies.
Used in Chemical Synthesis:
In the chemical synthesis industry, 1H-Isoindol-1-one, 6-amino-4-fluoro-2,3-dihydroserves as a key component in the creation of a wide range of organic compounds. Its reactivity and structural features facilitate the production of diverse chemical products, contributing to the advancement of organic chemistry.
Used in Drug Development:
1H-Isoindol-1-one, 6-amino-4-fluoro-2,3-dihydrois utilized as a starting material in drug development, where its properties can be leveraged to design and create novel pharmaceutical agents. 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-'s potential applications in this field highlight its importance in the ongoing pursuit of innovative treatments and therapies.

Upstream product

• 1036389-07-7 5-amino-2-cyano-3-fluorobenzoate methyl ester 
• 1036390-98-3 6-amino-2-cyano-3-fluorobenzoate methyl ester 
• 881415-28-7 2-bromo-3-fluoro-5-nitrobenzoic acid 
• 881415-30-1 2-bromo-3-fluoro-5-nitrobenzoate methyl ester 
• 1036389-05-5 5-amino-2-bromo-3-fluorobenzoate methyl ester 
• 132715-69-6 2-bromo-3-fluoro-benzoic acid 

Downstream Products

• 1036389-11-3 C₁₈H₁₇FN₂O₅ 

Relevant articles and documents

Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors

Inhibitors of Factor VIIa (FVIIa), a serine protease in the clotting cascade, have shown strong antithrombotic efficacy in preclinical thrombosis models with minimal bleeding liabilities. Discovery of potent, orally active FVIIa inhibitors has been largely unsuccessful because known chemotypes have required a highly basic group in the S1 binding pocket for high affinity. A recently reported fragment screening effort resulted in the discovery of a neutral heterocycle, 7-chloro-3,4-dihydroisoquinolin-1(2H)-one, that binds in the S1 pocket of FVIIa and can be incorporated into a phenylglycine FVIIa inhibitor. Optimization of this P1 binding group led to the first series of neutral, permeable FVIIa inhibitors with low nanomolar potency.

A kind of diaryl hydanto?n derivatives, its preparation method, pharmaceutical composition and application

Provided are a compound as represented by formula I, or pharmaceutically acceptable salt, solvate, precursor drug, stereoisomer, tautomer, polymorph or metabolite thereof, pharmaceutical composition containing same, and uses thereof in the preparation of drugs for treating androgen receptor related diseases.

BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.