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1H-Isoindol-1-one, 6-amino-4-fluoro-2,3-dihydro-, also known as a fluoro-substituted isoindolone, is a chemical compound with the molecular formula C8H8FNO. It features a cyclic structure with a lactam functional group and the presence of an amino and a fluoro substituent. 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydrois a valuable building block in organic chemistry and holds potential for pharmaceutical and medicinal applications, particularly in the development of new drugs and therapies.

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  • 1036389-09-9 Structure
  • Basic information

    1. Product Name: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-
    2. Synonyms: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-;6-Amino-4-fluoro-2,3-dihydro-1H-isoindol-1-one;6-Amino-4-fluoroisoindolin-1-one;6-Amino-4-fluoro-2,3-dihydroisoindol-1-one
    3. CAS NO:1036389-09-9
    4. Molecular Formula: C8H7FN2O
    5. Molecular Weight: 166.1523832
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1036389-09-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-(1036389-09-9)
    11. EPA Substance Registry System: 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-(1036389-09-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1036389-09-9(Hazardous Substances Data)

1036389-09-9 Usage

Uses

Used in Pharmaceutical Research:
1H-Isoindol-1-one, 6-amino-4-fluoro-2,3-dihydrois used as a chemical intermediate for the synthesis of various organic compounds and materials. Its unique structure and functional groups make it a promising candidate for the development of new drugs and therapies.
Used in Chemical Synthesis:
In the chemical synthesis industry, 1H-Isoindol-1-one, 6-amino-4-fluoro-2,3-dihydroserves as a key component in the creation of a wide range of organic compounds. Its reactivity and structural features facilitate the production of diverse chemical products, contributing to the advancement of organic chemistry.
Used in Drug Development:
1H-Isoindol-1-one, 6-amino-4-fluoro-2,3-dihydrois utilized as a starting material in drug development, where its properties can be leveraged to design and create novel pharmaceutical agents. 1H-Isoindol-1-one, 6-aMino-4-fluoro-2,3-dihydro-'s potential applications in this field highlight its importance in the ongoing pursuit of innovative treatments and therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 1036389-09-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,6,3,8 and 9 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1036389-09:
(9*1)+(8*0)+(7*3)+(6*6)+(5*3)+(4*8)+(3*9)+(2*0)+(1*9)=149
149 % 10 = 9
So 1036389-09-9 is a valid CAS Registry Number.

1036389-09-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-amino-4-fluoro-2,3-dihydroisoindol-1-one

1.2 Other means of identification

Product number -
Other names 6-Amino-4-fluoroisoindolin-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1036389-09-9 SDS

1036389-09-9Downstream Products

1036389-09-9Relevant articles and documents

Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors

Wurtz, Nicholas R.,Parkhurst, Brandon L.,Jiang, Wen,DeLucca, Indawati,Zhang, Xiaojun,Ladziata, Vladimir,Cheney, Daniel L.,Bozarth, Jeffrey R.,Rendina, Alan R.,Wei, Anzhi,Luettgen, Joseph M.,Wu, Yiming,Wong, Pancras C.,Seiffert, Dietmar A.,Wexler, Ruth R.,Priestley, E. Scott

supporting information, p. 1077 - 1081 (2016/12/18)

Inhibitors of Factor VIIa (FVIIa), a serine protease in the clotting cascade, have shown strong antithrombotic efficacy in preclinical thrombosis models with minimal bleeding liabilities. Discovery of potent, orally active FVIIa inhibitors has been largely unsuccessful because known chemotypes have required a highly basic group in the S1 binding pocket for high affinity. A recently reported fragment screening effort resulted in the discovery of a neutral heterocycle, 7-chloro-3,4-dihydroisoquinolin-1(2H)-one, that binds in the S1 pocket of FVIIa and can be incorporated into a phenylglycine FVIIa inhibitor. Optimization of this P1 binding group led to the first series of neutral, permeable FVIIa inhibitors with low nanomolar potency.

A kind of diaryl hydanto?n derivatives, its preparation method, pharmaceutical composition and application

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Paragraph 0147; 0205, (2016/10/20)

Provided are a compound as represented by formula I, or pharmaceutically acceptable salt, solvate, precursor drug, stereoisomer, tautomer, polymorph or metabolite thereof, pharmaceutical composition containing same, and uses thereof in the preparation of drugs for treating androgen receptor related diseases.

BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

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Page/Page column 107-108, (2008/12/07)

The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

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