1036389-20-4 Usage
Uses
Used in Pharmaceutical Industry:
6-Amino-7-fluoroisoindolin-1-one is used as a pharmaceutical intermediate for its potential role in the synthesis of biologically active compounds. Its unique structure and properties make it a valuable building block in the development of new drug candidates, particularly those targeting various diseases and conditions.
Used in Drug Synthesis:
6-Amino-7-fluoroisoindolin-1-one is used as a key component in the synthesis of various drug molecules. Its presence in the molecular structure can impart specific biological activities and properties to the resulting compounds, making it an essential component in the development of novel therapeutic agents.
Used in Medicinal Chemistry Research:
6-Amino-7-fluoroisoindolin-1-one is utilized in medicinal chemistry research to explore its potential as a lead compound or as a structural motif in the design of new pharmaceuticals. Its unique characteristics and reactivity can provide insights into the development of innovative drug candidates with improved efficacy and selectivity.
Used in Drug Discovery:
6-Amino-7-fluoroisoindolin-1-one is employed in drug discovery processes to identify and optimize potential drug candidates. Its incorporation into various chemical libraries can facilitate the screening and evaluation of novel compounds with therapeutic potential, ultimately contributing to the advancement of new treatments for various diseases and conditions.
Used in Chemical Synthesis:
6-Amino-7-fluoroisoindolin-1-one is used as a versatile building block in chemical synthesis, allowing for the creation of a wide range of compounds with diverse applications. Its unique properties and reactivity make it a valuable component in the synthesis of various organic and inorganic compounds, expanding its utility beyond the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1036389-20-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,6,3,8 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1036389-20:
(9*1)+(8*0)+(7*3)+(6*6)+(5*3)+(4*8)+(3*9)+(2*2)+(1*0)=144
144 % 10 = 4
So 1036389-20-4 is a valid CAS Registry Number.
1036389-20-4Relevant articles and documents
Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors
Wurtz, Nicholas R.,Parkhurst, Brandon L.,Jiang, Wen,DeLucca, Indawati,Zhang, Xiaojun,Ladziata, Vladimir,Cheney, Daniel L.,Bozarth, Jeffrey R.,Rendina, Alan R.,Wei, Anzhi,Luettgen, Joseph M.,Wu, Yiming,Wong, Pancras C.,Seiffert, Dietmar A.,Wexler, Ruth R.,Priestley, E. Scott
, p. 1077 - 1081 (2016/12/18)
Inhibitors of Factor VIIa (FVIIa), a serine protease in the clotting cascade, have shown strong antithrombotic efficacy in preclinical thrombosis models with minimal bleeding liabilities. Discovery of potent, orally active FVIIa inhibitors has been largely unsuccessful because known chemotypes have required a highly basic group in the S1 binding pocket for high affinity. A recently reported fragment screening effort resulted in the discovery of a neutral heterocycle, 7-chloro-3,4-dihydroisoquinolin-1(2H)-one, that binds in the S1 pocket of FVIIa and can be incorporated into a phenylglycine FVIIa inhibitor. Optimization of this P1 binding group led to the first series of neutral, permeable FVIIa inhibitors with low nanomolar potency.
