1036389-20-4 Usage
General Description
6-Amino-7-fluoroisoindolin-1-one is a chemical compound with the molecular formula C8H6FNO. It is a fluorinated isoindolinone derivative that has shown potential as a building block for the synthesis of biologically active compounds. This chemical has been investigated for its potential as a pharmaceutical intermediate and may have applications in the development of new drug candidates. It is important to note that further research and testing are necessary to fully understand the potential uses and effects of 6-Amino-7-fluoroisoindolin-1-one in various fields, including medicine and materials science. Additionally, proper handling and storage procedures should be followed when working with this chemical due to potential hazards associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 1036389-20-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,6,3,8 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1036389-20:
(9*1)+(8*0)+(7*3)+(6*6)+(5*3)+(4*8)+(3*9)+(2*2)+(1*0)=144
144 % 10 = 4
So 1036389-20-4 is a valid CAS Registry Number.
1036389-20-4Relevant articles and documents
Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors
Wurtz, Nicholas R.,Parkhurst, Brandon L.,Jiang, Wen,DeLucca, Indawati,Zhang, Xiaojun,Ladziata, Vladimir,Cheney, Daniel L.,Bozarth, Jeffrey R.,Rendina, Alan R.,Wei, Anzhi,Luettgen, Joseph M.,Wu, Yiming,Wong, Pancras C.,Seiffert, Dietmar A.,Wexler, Ruth R.,Priestley, E. Scott
supporting information, p. 1077 - 1081 (2016/12/18)
Inhibitors of Factor VIIa (FVIIa), a serine protease in the clotting cascade, have shown strong antithrombotic efficacy in preclinical thrombosis models with minimal bleeding liabilities. Discovery of potent, orally active FVIIa inhibitors has been largely unsuccessful because known chemotypes have required a highly basic group in the S1 binding pocket for high affinity. A recently reported fragment screening effort resulted in the discovery of a neutral heterocycle, 7-chloro-3,4-dihydroisoquinolin-1(2H)-one, that binds in the S1 pocket of FVIIa and can be incorporated into a phenylglycine FVIIa inhibitor. Optimization of this P1 binding group led to the first series of neutral, permeable FVIIa inhibitors with low nanomolar potency.
