1036390-32-5

Basic information

• Product Name: 7-amino-4-chloro-1,2-dihydroisoquinolin-1-one
• Synonyms: 7-amino-4-chloro-1,2-dihydroisoquinolin-1-one;7-AMINO-4-CHLORO-1(2H)-ISOQUINOLINONE
• CAS NO: 1036390-32-5
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.61768
• Mol File: 1036390-32-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-amino-4-chloro-1,2-dihydroisoquinolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-amino-4-chloro-1,2-dihydroisoquinolin-1-one(1036390-32-5)
• EPA Substance Registry System: 7-amino-4-chloro-1,2-dihydroisoquinolin-1-one(1036390-32-5)

Safety Data

• Hazardous Substances Data: 1036390-32-5(Hazardous Substances Data)

Upstream product

• 1036388-65-4 2-(2,4-dimethoxybenzyl)-7-nitroisoquinolin-1(2H)-one 
• 1036388-63-2 (E)-methyl 2-(2-(dimethylamino)vinyl)-5-nitrobenzoate 
• 64688-68-2 2-methyl-5-nitrobenzoyl chloride 
• 77324-87-9 methyl 2-methyl-5-nitrobenzoate 
• 1975-52-6 5-nitro-o-toluic acid 
• 1036390-30-3 4-chloro-7-nitroisoquinolin-1(2H)-one 

Relevant articles and documents

Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors

Inhibitors of Factor VIIa (FVIIa), a serine protease in the clotting cascade, have shown strong antithrombotic efficacy in preclinical thrombosis models with minimal bleeding liabilities. Discovery of potent, orally active FVIIa inhibitors has been largely unsuccessful because known chemotypes have required a highly basic group in the S1 binding pocket for high affinity. A recently reported fragment screening effort resulted in the discovery of a neutral heterocycle, 7-chloro-3,4-dihydroisoquinolin-1(2H)-one, that binds in the S1 pocket of FVIIa and can be incorporated into a phenylglycine FVIIa inhibitor. Optimization of this P1 binding group led to the first series of neutral, permeable FVIIa inhibitors with low nanomolar potency.

MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

The present invention relates generally to novel macrocycles of Formula (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z1, Z2, Z3, Z4, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.