1036392-21-8Relevant articles and documents
Cytosporin-related compounds from the marine-derived fungus Eutypella scoparia
Ciavatta, Maria Letizia,Lopez-Gresa, M. Pilar,Gavagnin, Margherita,Nicoletti, Rosario,Manzo, Emiliano,Mollo, Ernesto,Guo, Yue-Wei,Cimino, Guido
, p. 5365 - 5369 (2008)
Chemical investigation of the culture broth of the fungus Eutypella scoparia ICB-OBX, isolated from the marine pulmonate mollusc Onchidium sp., led to the finding of novel compounds 1 and 2, structurally related to angiotensin II binding inhibitors cytosporins, along with unrelated known nitrogen metabolites (compounds 3-5). The structure and the relative stereochemistry of the novel metabolites were assigned mainly by a detailed analysis of two-dimensional NMR techniques whereas the absolute stereochemistry was proposed by modified Mosher's method. Compound 2 contains an unusual cyclic carbonate functionality that is rare among natural products.