1036406-51-5

Basic information

• Product Name: diethyl 3-methyl-1-(N-phenylamino)butylphosphonate
• Synonyms: diethyl 3-methyl-1-(N-phenylamino)butylphosphonate
• CAS NO: 1036406-51-5
• Molecular Weight: 299.35
• Mol File: 1036406-51-5.mol

Chemical Properties

• CAS DataBase Reference: diethyl 3-methyl-1-(N-phenylamino)butylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 3-methyl-1-(N-phenylamino)butylphosphonate(1036406-51-5)
• EPA Substance Registry System: diethyl 3-methyl-1-(N-phenylamino)butylphosphonate(1036406-51-5)

Safety Data

• Hazardous Substances Data: 1036406-51-5(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 762-04-9 phosphonic acid diethyl ester 
• 590-86-3 isovaleraldehyde 

Relevant articles and documents

Silica sulfuric acid as a recyclable catalyst for a one-pot synthesis of α-aminophosphonates in solvent-free conditions

A simple and efficient method has been developed for the synthesis of a-aminophosphonates by a one-pot three-component condensation of aldehydes, amines and diethyl phosphite in the presence of a catalytic amount of silica sulfuric acid under solvent-free reaction conditions. The major advantages of the present method are good yields, inexpensive, ecofriendly and reusable catalyst, short reaction times, mild and solvent-free reaction conditions.

Tin(II) compounds as catalysts for the Kabachnik-fields reaction under solvent-free conditions: Facile synthesis of α -aminophosphonates

In the presence of a catalytic amount of tin(II) salts, the three-component Kabachnik-Fields reaction involving aldehydes, amines, and diethyl phosphite proceeded smoothly to afford the corresponding -aminophosphonates in good to high yields. These reactions were carried out under solvent-free conditions.

TiO2 as a new and reusable catalyst for one-pot three-component syntheses of α-aminophosphonates in solvent-free conditions

Commercially available titania (TiO2) is reported as an extremely efficient catalyst for the synthesis of α-aminophosphonates. A three-component reaction of an amine, an aldehyde or a ketone and a dialkyl phosphite (Kabachnik-Fields reaction) took place in one-pot, under solvent-free conditions to afford the corresponding α-aminophosphonates in high yields and short times. The TiO2 catalyzed α-aminophosphonate synthesis in the present study perhaps represents a true three-component reaction as no intermediate formation of either an imine or α-hydroxyphosphonate was observed that indicated the simultaneous involvement of the carbonyl compound, the amine and the phosphite in the transition state. Furthermore, the catalyst can be reused for several times without any significant loss of catalytic activity.