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N-(3-aminophenyl)-N'-(2-methylphenyl)urea is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1036431-96-5 Structure
  • Basic information

    1. Product Name: N-(3-aminophenyl)-N'-(2-methylphenyl)urea
    2. Synonyms: N-(3-aminophenyl)-N'-(2-methylphenyl)urea
    3. CAS NO:1036431-96-5
    4. Molecular Formula:
    5. Molecular Weight: 241.293
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1036431-96-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(3-aminophenyl)-N'-(2-methylphenyl)urea(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(3-aminophenyl)-N'-(2-methylphenyl)urea(1036431-96-5)
    11. EPA Substance Registry System: N-(3-aminophenyl)-N'-(2-methylphenyl)urea(1036431-96-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1036431-96-5(Hazardous Substances Data)

1036431-96-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1036431-96-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,6,4,3 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1036431-96:
(9*1)+(8*0)+(7*3)+(6*6)+(5*4)+(4*3)+(3*1)+(2*9)+(1*6)=125
125 % 10 = 5
So 1036431-96-5 is a valid CAS Registry Number.

1036431-96-5Relevant articles and documents

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

Radi, Marco,Falchi, Federico,Garbelli, Anna,Samuele, Alberta,Bernardo, Vincenzo,Paolucci, Stefania,Baldanti, Fausto,Schenone, Silvia,Manetti, Fabrizio,Maga, Giovanni,Botta, Maurizio

, p. 2094 - 2098 (2012)

Efficacy of currently approved anti-HIV drugs is hampered by mutations of the viral enzymes, leading invariably to drug resistance and chemotherapy failure. Recent data suggest that cellular co-factors also represent useful targets for anti-HIV therapy. H

Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity

Li, Xin-yang,Zhang, Ting-jian,Kamara, Mohamed Olounfeh,Lu, Guo-qing,Xu, Hai-li,Wang, De-pu,Meng, Fan-hao

, (2019/07/16)

Thymidylate synthase (TS) is a hot target for tumor chemotherapy, and its inhibitors are an essential direction for anti-tumor drug research. To our knowledge, currently, there are no reported thymidylate synthase inhibitors that could inhibit cancer cell migration. Therefore, for optimal therapeutic purposes, combines our previous reports and findings, we hope to obtain a multi-effects inhibitor. This study according to the principle of flattening we designed and synthesized 18 of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)phenyl urea derivatives as multi-effects inhibitors. The biological evaluation results showed that target compounds could significantly inhibit the hTS enzyme, BRaf kinase and EGFR kinase activity in vitro, and most of the compounds had excellent anti-cell viability for six cancer cell lines. Notably, the candidate compound L14e (IC50 = 0.67 μM) had the superior anti-cell viability and safety to A549 and H460 cells compared with pemetrexed. Further studies had shown that L14e could cause G1/S phase arrest then induce intrinsic apoptosis. Transwell, western blot, and tube formation results proved that L14e could inhibit the activation of the EGFR signaling pathway, then ultimately achieve the purpose of inhibiting cancer cell migration and angiogenesis in cancer tissues. Furthermore, in vivo pharmacology evaluations of L14e showed significant antitumor activity in A549 cells xenografts with minimal toxicity. All of these results demonstrated that the L14e has the potential for drug discovery as a multi-effects inhibitor and provides a new reference for clinical treatment of non-small cell lung cancer.

Pyrimidine phenylurea anti-tumor compound and preparation method and application thereof

-

, (2018/12/05)

The invention belongs to the field of medicines, and particularly relates to a pyrimidine phenylurea anti-tumor compound and a preparation method and application thereof. A structure general formula of the pyrimidine phenylurea anti-tumor compound is spec

COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF

-

Page/Page column 147, (2011/04/25)

The present invention relates to the medical use of the compound of formula 1,2,3 or 4

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