1036487-55-4

Basic information

• Product Name: 3-(4'-chloro-2'-fluorophenyl)isocoumarin
• Synonyms: 3-(4'-chloro-2'-fluorophenyl)isocoumarin
• CAS NO: 1036487-55-4
• Molecular Weight: 274.679
• Mol File: 1036487-55-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4'-chloro-2'-fluorophenyl)isocoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4'-chloro-2'-fluorophenyl)isocoumarin(1036487-55-4)
• EPA Substance Registry System: 3-(4'-chloro-2'-fluorophenyl)isocoumarin(1036487-55-4)

Safety Data

• Hazardous Substances Data: 1036487-55-4(Hazardous Substances Data)

Upstream product

• 1363189-09-6 2-{2'-(4''-chloro-2''-fluorophenyl)-2'-oxoethyl}benzoic acid 
• 89-51-0 Homophthalic acid 
• 394-39-8 4-chloro-2-fluorobenzoyl chloride 

Downstream Products

• 1036487-52-1 3-(2-chloro-4-fluorophenyl)-1H-isochromene-1-thione 
• 1363189-09-6 2-{2'-(4''-chloro-2''-fluorophenyl)-2'-oxoethyl}benzoic acid 
• 1363189-50-7 (dl)-3-(4'-chloro-2'-fluorophenyl)-3,4-dihydroisocoumarin 
• 1363189-69-8 3-(4'-chloro-2'-fluorophenyl)thioisocoumarin 
• 1363189-29-0 C₁₅H₁₂ClFO₃ 

Relevant articles and documents

Synthesis and anti-cancer, anti-metastatic evaluation of some new fluorinated isocoumarins and 3,4-dihydroisocoumarins

Synthesis of some fluorinated isocoumarins and 3,4-dihydroisocoumarins is reported. Structures of the synthesized compounds were confirmed by spectral and elemental analysis. All the synthesized compounds were evaluated for their antimetastatic activity and anti-cancer activity against breast cell line (MCF-7). Among all the tested compounds 3h [3-(3′,4′-difluorophenyl) isocoumarin] has shown excellent antimetastatic activity, however the growth inhibitory response of the tested compounds [3a-h, 4a-h, 5e-h, 6a-h and 7a, c, d] for MCF-7 human breast carcinoma cell line was moderate at higher concentrations (100-400 μM) and negligible at lower concentrations.