1036712-62-5

Upstream product

• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 1036712-61-4 N-[(3-bromo-4-fluoro-phenyl)methyl]-2,2-dimethoxy-ethanamine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 923022-40-6 7-bromo-6-fluoroisoquinoline 

Relevant academic research and scientific papers

PLASMA KALLIKREIN INHIBITORS

The present invention provides compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLONE AND ISOQUINOLINONE DERIVATIVES

The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula 1 useful for the treatment and prevention of diseases associated with Rho-kinase and Rho- kinase mediated phosphorylation of myosin light chain phosphatase, and composition containing such compound