103675-99-6

Basic information

• Product Name: (4-BROMOPHENYL)ACETONE OXIME
• Synonyms: (4-BROMOPHENYL)ACETONE OXIME;2-PROPANONE, 1-(4-BROMOPHENYL)-, OXIME
• CAS NO: 103675-99-6
• Molecular Formula: C₉H₁₀BrNO
• Molecular Weight: 228.09
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 103675-99-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-BROMOPHENYL)ACETONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMOPHENYL)ACETONE OXIME(103675-99-6)
• EPA Substance Registry System: (4-BROMOPHENYL)ACETONE OXIME(103675-99-6)

Safety Data

• Hazardous Substances Data: 103675-99-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(4-BROMOPHENYL)ACETONE OXIME is used as a reagent for facilitating various chemical reactions and organic synthesis processes. Its unique structure allows it to participate in a range of reactions, making it a versatile compound in the field of chemistry.
Used in Pharmaceutical and Agrochemical Production:
(4-BROMOPHENYL)ACETONE OXIME is used as a building block in the production of pharmaceuticals and agrochemicals. Its role in creating the backbone of these compounds contributes to their overall effectiveness and function.
Used in Research and Development:
In the realm of research and development, (4-BROMOPHENYL)ACETONE OXIME is used as a tool to investigate chemical and biological processes. Its properties and reactivity provide valuable insights into the behavior of similar compounds and can lead to advancements in understanding complex chemical interactions.
Used in Pharmaceutical Manufacturing:
(4-BROMOPHENYL)ACETONE OXIME is employed in the synthesis of various drugs and drug intermediates. Its presence in the manufacturing process is crucial for the development of new medications and the improvement of existing ones, ultimately contributing to advancements in healthcare and medicine.
Used in Chemical Intermediate Synthesis:
(4-BROMOPHENYL)ACETONE OXIME is used as a chemical intermediate in the synthesis of other organic compounds. Its role in creating intermediates is essential for the production of a wide range of chemical products, from pharmaceuticals to industrial chemicals.

Upstream product

• 21892-60-4 1-(p-Bromphenyl)-2-nitro-1-propen 
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Downstream Products

• 877203-65-1 2-(4-bromo-phenyl)-3-methyl-2H-azirine 
• 6127-19-1 6-bromo-2-methyl-1H-indole 

Relevant articles and documents

Copper-Catalyzed Aza-Sonogashira Cross-Coupling To Form Ynimines: Development and Application to the Synthesis of Heterocycles

Nitrogen-substituted alkynes, such as ynamines and ynamides, are versatile synthetic building blocks. Ynimines bearing additional nucleophilic and electrophilic centers relative to ynamines and ynamides are expected to have high synthetic potential. However, their chemical reactivity remains unexplored owing mainly to the lack of synthetic accessibility. We report herein a versatile copper-catalyzed synthesis of ynimines from readily available O-acetyl ketoximes and terminal alkynes. A wide range of O-acetyl ketoximes derived from diaryl ketones, aryl alkyl ketones and dialkyl ketones underwent cross-coupling with a diverse set of terminal alkynes to afford the ynimines in good to excellent yields. An unprecedented [5+1] heteroannulation reaction exploiting the reactivity of the ynimine generated in situ was subsequently developed for the synthesis of medicinally important heterocycles, including isoquinolines, azaindoles, azabenzofurans, azabenzothiophenes and carbolines.

The Neber route to substituted indoles

Two complementary procedures have been developed for the conversion of the oximes of α-aryl ketones to azirines. On heating, the azirines rearrange smoothly to the corresponding indoles. The overall transformation offers a versatile route to indoles, complementary to the Fischer indole synthesis. Copyright

The Palladium Assisted Transfer Reduction of α,β-Unsaturated Nitroalkenes to Oximes Using Ammonium Formate

α,β-Unsaturated nitroalkenes are readily reduced to the corresponding oximes in good yields using ammonium formate in the presence of palladium.The reactions occur rapidly at room temperature in a solvent system of methanol and tetrahydrofuran.

THE PALLADIUM ASSISTED TRANSFER REDUCTION OF α,β-UNSATURATED NITROALKENES USING SODIUM HYPOPHOSPHITE: A SYNTHESIS OF OXIMES

α,β-Unsaturated nitroalkenes are readily reduced by sodium hypophosphite to the corresponding oximes in the presence of palladium.

A FACILE KETOXIME PREPARATION VIA THE REDUCTION OF Αa,β-UNSATURATED NITROALKENES USING SODIUM STANNITE

α,β-Unsaturated nitroalkenes are readily reduced by sodium stannite to ketoximes at room temperature.