1036750-28-3

Basic information

• Product Name: C₁₇H₁₅ClN₂O₂
• Synonyms: C₁₇H₁₅ClN₂O₂
• CAS NO: 1036750-28-3
• Molecular Weight: 314.771
• Mol File: 1036750-28-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₅ClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₅ClN₂O₂(1036750-28-3)
• EPA Substance Registry System: C₁₇H₁₅ClN₂O₂(1036750-28-3)

Safety Data

• Hazardous Substances Data: 1036750-28-3(Hazardous Substances Data)

Upstream product

• 10517-21-2 5-chloro-1H-Indole-2-carboxylic acid 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 

Relevant articles and documents

Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a

A series of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives were prepared and evaluated as inhibitors of human liver glycogen phosphorylase a (hLGPa). One compound, 5-chloro-N-[4-(1,2-dihydroxyethyl)phenyl]-1H-indole-2-carboxamide (2f), inhibited hLGPa with an IC50 of 0.90 μM. The pyridine analogue of 2f showed inhibitory activity of glucagon-induced glucose output in cultured primary hepatocytes with an IC50 of 0.62 μM and oral hypoglycemic activity in diabetic db/db mice. Crystallographic determination of the complex of 2f with hLGPa showed binding of the inhibitor in a solvent cavity at the dimer interface, with the two hydroxyl groups making favorable electrostatic interactions with hLGPa.