1036757-43-3Relevant articles and documents
PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
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Paragraph 0565; 0567-0568, (2022/02/28)
The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (I), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment of diseases including heart (e.g. ischemic heart disease, congestive heart failure, and valvular heart disease), lung (e.g., lung inflammation, pneumonia, acute lung injury, pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease), respiratory (e.g., respiratory infection, acute respiratory distress syndrome), liver (e.g. acute liver failure and liver fibrosis and cirrhosis), and kidney (e.g. acute kidney injury and chronic kidney disease) disease, inflammatory bowel disease (IBD), ischemic reperfusion injury (e.g., stroke), and retinopathy of prematurity (ROP).
DGAT1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF
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Paragraph 0277; 0278, (2016/08/23)
The present invention discloses a novel DGAT1 inhibitor, especially the compound of formula (I) or a pharmaceutically acceptable salt thereof, preparation and pharmaceutical composition thereof, as well as their uses in the preparation of a medicament for the prevention and treatment of Familial hyperchylomicronemia (FCS), obesity, hyperlipoproteinemia or hypertriglyceridemia.
ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
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Paragraph 0216-0217, (2014/09/30)
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase
Yin, Zheng,Chen, Yen-Liang,Kondreddi, Ravinder Reddy,Chan, Wai Ling,Wang, Gang,Ng, Ru Hui,Lim, Joanne Y. H.,Lee, Wan Yen,Jeyaraj, Duraiswamy A.,Niyomrattanakit, Pornwaratt,Wen, Daying,Chao, Alex,Glickman, J. Fraser,Voshol, Hans,Mueller, Dieter,Spanka, Carsten,Dressler, Sigmar,Nilar, Shahul,Vasudevan, Subhash G.,Shi, Pei-Yong,Keller, Thomas H.
supporting information; experimental part, p. 7934 - 7937 (2010/07/07)
A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.