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1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)is a pyrazole derivative with the molecular formula C12H22BNO2. It features a boron atom and a 2-methylpropyl group, making it a versatile building block in organic synthesis. 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)is particularly valuable in the field of medicinal chemistry for the synthesis of pharmaceuticals, agrochemicals, and other biologically active molecules. Its boron atom also facilitates cross-coupling reactions, enabling the formation of complex carbon-carbon bonds. As a result, 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)has potential applications in the development of new materials and bioactive compounds.

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  • 1-(2-METHYLPROPYL)-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

    Cas No: 1036757-43-3

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  • 1036757-43-3 Structure
  • Basic information

    1. Product Name: 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
    2. Synonyms: 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Isobutyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Isobutyl-1H-pyrazole-3-boronic acid pinacol ester;1-(2-methylpropyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
    3. CAS NO:1036757-43-3
    4. Molecular Formula: C13H23BN2O2
    5. Molecular Weight: 250.14492
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1036757-43-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-(1036757-43-3)
    11. EPA Substance Registry System: 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-(1036757-43-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1036757-43-3(Hazardous Substances Data)

1036757-43-3 Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)is used as a building block for the synthesis of pharmaceuticals due to its ability to form complex carbon-carbon bonds and its potential to create biologically active molecules.
Used in Agrochemical Industry:
In the agrochemical industry, 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)is utilized as a precursor for the development of agrochemicals, leveraging its reactivity and structural features to create effective compounds for agricultural applications.
Used in Organic Synthesis:
1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)is used as a reagent in organic synthesis for the formation of complex carbon-carbon bonds through cross-coupling reactions, contributing to the creation of new materials and compounds with diverse applications.
Used in Medicinal Chemistry Research:
As a component in medicinal chemistry research, 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)is employed for the exploration and development of new bioactive molecules, potentially leading to the discovery of novel therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 1036757-43-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,6,7,5 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1036757-43:
(9*1)+(8*0)+(7*3)+(6*6)+(5*7)+(4*5)+(3*7)+(2*4)+(1*3)=153
153 % 10 = 3
So 1036757-43-3 is a valid CAS Registry Number.

1036757-43-3Downstream Products

1036757-43-3Relevant articles and documents

PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

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Paragraph 0565; 0567-0568, (2022/02/28)

The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (I), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment of diseases including heart (e.g. ischemic heart disease, congestive heart failure, and valvular heart disease), lung (e.g., lung inflammation, pneumonia, acute lung injury, pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease), respiratory (e.g., respiratory infection, acute respiratory distress syndrome), liver (e.g. acute liver failure and liver fibrosis and cirrhosis), and kidney (e.g. acute kidney injury and chronic kidney disease) disease, inflammatory bowel disease (IBD), ischemic reperfusion injury (e.g., stroke), and retinopathy of prematurity (ROP).

DGAT1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

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Paragraph 0277; 0278, (2016/08/23)

The present invention discloses a novel DGAT1 inhibitor, especially the compound of formula (I) or a pharmaceutically acceptable salt thereof, preparation and pharmaceutical composition thereof, as well as their uses in the preparation of a medicament for the prevention and treatment of Familial hyperchylomicronemia (FCS), obesity, hyperlipoproteinemia or hypertriglyceridemia.

ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF

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Paragraph 0216-0217, (2014/09/30)

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

Yin, Zheng,Chen, Yen-Liang,Kondreddi, Ravinder Reddy,Chan, Wai Ling,Wang, Gang,Ng, Ru Hui,Lim, Joanne Y. H.,Lee, Wan Yen,Jeyaraj, Duraiswamy A.,Niyomrattanakit, Pornwaratt,Wen, Daying,Chao, Alex,Glickman, J. Fraser,Voshol, Hans,Mueller, Dieter,Spanka, Carsten,Dressler, Sigmar,Nilar, Shahul,Vasudevan, Subhash G.,Shi, Pei-Yong,Keller, Thomas H.

supporting information; experimental part, p. 7934 - 7937 (2010/07/07)

A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.

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