1036760-44-7Relevant articles and documents
New ligands and structural insights into the catalytic asymmetric addition of organozinc reagents to ketones
Huelgas, Gabriela,Larochelle, Lynne K.,Rivas, Lucrecia,Luchinina, Yekaterina,Toscano, Rubén A.,Carroll, Patrick J.,Walsh, Patrick J.,Anaya De Parrodi, Cecilia
, p. 4467 - 4474 (2011)
The catalytic asymmetric addition of alkyl groups to ketones has received considerable attention. Outlined herein is the synthesis of two new ligands based on the C2-symmetric 11,12-diamino-9,10-dihydro-9,10- ethanoanthracene. The scope of the new ligands has been evaluated in the catalytic asymmetric addition of diethylzinc to a variety of ketones. Enantioselectivities as high as 99% have been achieved. The structures of two of these ligands have been determined by X-ray crystallography and are compared with related structures. Additionally, the structure of a titanium complex bound to a bis(sulfonamide) diol ligand is reported.
Study of syntheses and specific rotations of (S)-3-phenylhexan-3-ol and its derivatives
Liao, Tou-Gen,Ren, Jie,Fan, Hua-Fang,Xie, Ming-Jin,Zhu, Hua-Jie
, p. 808 - 815 (2008/09/21)
Tertiary alcohols, 3-phenylhexan-3-ol and 3-methylhexane-3-ol, and their derivatives were synthesized. The reaction conditions of the esterification of the tertiary alcohol with 2-NO2PhCO2Cl and 4-NO2PhCO2Cl were optimized. The absolute configuration of the derivative from (S)-3-phenylhexan-3-ol was identified by X-ray study and computational methods. Experimental results confirmed the computational specific rotation predictions by DFT-based and matrix methods.
