1036765-52-2

Basic information

• Product Name: 3-acetyl-1-(4-fluorobenzyl)-6-methoxy-1H-indole
• Synonyms: 3-acetyl-1-(4-fluorobenzyl)-6-methoxy-1H-indole
• CAS NO: 1036765-52-2
• Molecular Weight: 297.329
• Mol File: 1036765-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-acetyl-1-(4-fluorobenzyl)-6-methoxy-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetyl-1-(4-fluorobenzyl)-6-methoxy-1H-indole(1036765-52-2)
• EPA Substance Registry System: 3-acetyl-1-(4-fluorobenzyl)-6-methoxy-1H-indole(1036765-52-2)

Safety Data

• Hazardous Substances Data: 1036765-52-2(Hazardous Substances Data)

Upstream product

• 459-46-1 4-Fluorobenzyl bromide 
• 99532-52-2 1-(6-methoxy-1H-indol-3-yl)ethan-1-one 

Relevant articles and documents

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series

We report herein the development of a new three-dimensional pharmacophore model for HIV-1 integrase inhibitors which led to the discovery of some 4-[1-(4-fluorobenzyl)-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acids that are able to specifically inhibit the strand transfer step of integration at nanomolar concentration. The synthesis of the new designed molecules is also described.