1036765-93-1

Basic information

• Product Name: 4-[1'-(4-hydroxy-4,4-diphenyl-butyl)-[4,4']bipiperidinyl-1-yl]-1,1-diphenyl-butan-1-ol
• CAS NO: 1036765-93-1
• Molecular Weight: 616.887
• Mol File: 1036765-93-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[1'-(4-hydroxy-4,4-diphenyl-butyl)-[4,4']bipiperidinyl-1-yl]-1,1-diphenyl-butan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[1'-(4-hydroxy-4,4-diphenyl-butyl)-[4,4']bipiperidinyl-1-yl]-1,1-diphenyl-butan-1-ol(1036765-93-1)
• EPA Substance Registry System: 4-[1'-(4-hydroxy-4,4-diphenyl-butyl)-[4,4']bipiperidinyl-1-yl]-1,1-diphenyl-butan-1-ol(1036765-93-1)

Safety Data

• Hazardous Substances Data: 1036765-93-1(Hazardous Substances Data)

Upstream product

• 15336-72-8 4,4'-bipiperidine 
• 63645-18-1 4-hydroxy-4,4-diphenylbutyl chloride 

Relevant articles and documents

Diphenidol-related diamines as novel muscarinic M4 receptor antagonists

A series of hydrochloride derivatives 2a-9a and quaternary ammonium derivatives 3b-9b of diphenidol have been synthesized and characterized in receptor binding and cellular functional assays versus human muscarinic M1-M5 receptors expressed in CHO cells. Compound 8b, a methiodide derivative with a bipiperidinyl moiety and a second diphenidol framework, showed a potent and selective M4 activity as competitive antagonist. Moreover 8b, acting as an allosteric modulator, was able to retard the dissociation rate of [3H]-N-methylscopolamine from CHO-M4 cell membranes exposed to atropine. Taken together, these data suggest that 8b might open new avenues to the discovery of novel multivalent antagonists for the muscarinic receptors.