1036968-29-2Relevant academic research and scientific papers
Reactions catalyzed by a binuclear copper complex: Selective oxidation of alkenes to carbonyls with O2
Liu, Yuxia,Xue, Dong,Li, Chaoqun,Xiao, Jianliang,Wang, Chao
, p. 5510 - 5514 (2017)
Terminal alkenes were selectively cleaved into ketones and aldehydes catalyzed by a binuclear copper catalyst bearing a simple salicylate ligand with O2 as the oxidant. The reaction was carried out under an atmosphere of O2 (balloon) with 0.5 mol% of catalyst and could be performed on a gram scale, providing a convenient and practical method for the cleavage of terminal alkenes into carbonyl compounds.
Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB
Mallari, Jeremy P.,Shelat, Anang,Kosinski, Aaron,Caffrey, Conor R.,Connelly, Michele,Zhu, Fangyi,McKerrow, James H.,Guy, R. Kiplin
, p. 2883 - 2885 (2008/12/22)
Human African trypanosomiasis (HAT) is caused by the protozoan parasite Trypanosoma brucei. The cysteine proteases of T. brucei have been shown to be crucial for parasite replication and represent an attractive point for therapeutic intervention. Herein we describe the synthesis of a series of thiosemicarbazones and their activity against the trypanosomal cathepsins TbcatB and rhodesain, as well as human cathepsins L and B. The activity of these compounds was determined against cultured T. brucei, and specificity was assessed with a panel of four mammalian cell lines.
