1037051-07-2Relevant academic research and scientific papers
Direct transition-metal-free intramolecular arylation of phenols
Bajracharya, Gan B.,Daugulis, Olafs
supporting information; experimental part, p. 4625 - 4628 (2009/05/13)
(Chemical Equation Presented) Direct transition-metal-free, base-mediated intramolecular arylation of phenols with aryl halides has been developed. In the presence of 2.5 equiv of t-BuOK in dioxane at 140 °C, the intramolecular cyclization of 3-(2-halobenzyloxy)phenols affords 6H-benzo[c]chromenes in high yields. This reaction proceeds by an initial formation of a benzyne intermediate followed by an aromatic sp2 C-H functionalization (a formal C-H activation) to form the carbon-carbon bond.
Palladium mediated bis- and tris-biaryl Heck coupling for the synthesis of heterocycles
Majumdar,Chakravorty,De
, p. 3419 - 3422 (2008/09/21)
A simple and straightforward palladium mediated ligand free bis- and tris-biaryl coupling on an unactivated phenylbenzyl ether system to produce hitherto unreported heterocyclic compound is described.
