1037059-40-7Relevant academic research and scientific papers
A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
Cardoso, Mariana F. C.,Da Silva, Illana M. C. B.,Dos Santos Jr., Helve?cio M.,Rocha, David R.,Arau?jo, Ana Je?rsia,Pessoa, Claudia,De Moraes, Manoel O.,Lotufo, Leti?cia V. C.,De C. Da Silva, Fernando,Santos, Wilson C.,Ferreira, Vitor F.
, p. 12 - 16 (2013/05/08)
Several studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering nor-β-lapachone as an important prototype, a set of new 3-substituted nor-β-lapachones was synthesized by a new synthetic route that involves the use of synthetic intermediate generated for coupling with several nucleophiles containing the carbohydrate and 2H-pyrazole substituent moieties. All the compounds were screened against four tumor cell lines. Two of the compounds showed moderate cytotoxicity, while the other compounds strongly inhibit all tested cancer cell lines.
3-Arylamino and 3-alkoxy-nor-β-lapachone derivatives: Synthesis and cytotoxicity against cancer cell lines
Da Silva Jr., Eufranio N.,De Deus, Clara F.,Cavalcanti, Bruno C.,Pessoa, Cláudia,Costa-Lotufo, Letícia V.,Montenegro, Raquel C.,De Moraes, Manoel O.,Pinto, Maria Do Carmo F. R.,De Simone, Carlos A.,Ferreira, Vitor F.,Goulart, Marilia O. F.,Andrade, Carlos Kleber Z.,Pinto, Ant?nio V.
experimental part, p. 504 - 508 (2010/05/02)
Several 3-arylamino and 3-alkoxy-nor-β-lapachone derivatives were synthesized in moderate to high yields and found to be highly potent against cancer cells SF295 (central nervous system),HCT8 (colon), MDA-MB435 (melanoma), and HL60 (leukemia), with ICsub
Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones
da Silva Junior, Eufranio N.,de Souza, Maria Cecilia B.V.,Fernandes, Michelle C.,Menna-Barreto, Rubem F.S.,Pinto, Maria do Carmo F.R.,de Assis Lopes, Francisco,de Simone, Carlos Alberto,Andrade, Carlos Kleber Z.,Pinto, Antonio V.,Ferreira, Vitor F.,de Castro, Solange L.
, p. 5030 - 5038 (2008/12/21)
New naphthoquinone derivatives were synthesized and assayed against bloodstream trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas' disease. The compounds were rationalized based on hybrid drugs and appear as important compounds ag
