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IPI-926 is a chemical compound that belongs to the class of hedgehog pathway inhibitors. It functions by targeting the hedgehog signaling pathway, which plays a crucial role in the growth and development of cancer cells. By inhibiting this pathway, IPI-926 has demonstrated the potential to block the growth and spread of cancer cells, especially in pancreatic, ovarian, and other solid tumor types. This makes IPI-926 a promising candidate for the treatment of various types of cancer, and it is currently under investigation in clinical trials to assess its effectiveness and safety in cancer therapy.

1037210-93-7

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1037210-93-7 Usage

Uses

Used in Oncology:
IPI-926 is used as an anticancer agent for its ability to inhibit the hedgehog signaling pathway, which is implicated in the growth and development of various types of cancer. It is particularly effective against pancreatic and ovarian cancers, as well as other solid tumor types.
Used in Clinical Trials:
IPI-926 is used as a subject of investigation in clinical trials to determine its effectiveness and safety in treating cancer. These trials aim to establish the optimal dosage, administration methods, and potential side effects of the compound, as well as to identify any synergistic effects when combined with other cancer therapies.
Used in Drug Development:
IPI-926 is used as a lead compound in the development of new cancer therapies. Its unique mechanism of action targeting the hedgehog signaling pathway offers a novel approach to treating cancer and may lead to the discovery of additional hedgehog pathway inhibitors with improved efficacy and reduced side effects.
Used in Cancer Research:
IPI-926 is used as a research tool to further understand the role of the hedgehog signaling pathway in cancer development and progression. Studies involving IPI-926 can provide valuable insights into the molecular mechanisms underlying cancer growth and help identify potential therapeutic targets for the development of new cancer treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 1037210-93-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,7,2,1 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1037210-93:
(9*1)+(8*0)+(7*3)+(6*7)+(5*2)+(4*1)+(3*0)+(2*9)+(1*3)=107
107 % 10 = 7
So 1037210-93-7 is a valid CAS Registry Number.

1037210-93-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide

1.2 Other means of identification

Product number -
Other names UNII-JT96FPU35X

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1037210-93-7 SDS

1037210-93-7Relevant academic research and scientific papers

A Design of Experiments Approach to a Robust Final Deprotection and Reactive Crystallization of IPI-926, A Novel Hedgehog Pathway Inhibitor

Martinot, Theodore A.,Austad, Brian C.,C?té, Alexandre,Depew, Kristopher M.,Genov, Daniel,Grenier, Louis,Helble, Joseph,Lescarbeau, Andre,Nair, Somarajan,Trudeau, Martin,White, Priscilla,Yu, Lin-Chen

, p. 1693 - 1702 (2015)

A design of experiments (DoE) approach was taken to optimize purity and reaction yield of the final debenzylation and hydrochloride salt formation of IPI-926. The study involved a careful dissection of the different process steps to enable an independent investigation of these steps while ensuring that process streams were representative. The results enabled a streamlined process from the final chemical transformation to the salting and isolation and led to the elimination of variability in the process as well as a robust control of impurities. The optimized process was applied to production and demonstrated on the kilogram scale.

ENZYMATIC TRANSAMINATION OF CYCLOPAMINE ANALOGS

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Page/Page column 15; 85-86, (2011/02/24)

Provided are processes for the synthesis of amino analogues from ketone starting materials

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

Tremblay, Martin R.,Lescarbeau, André,Grogan, Michael J.,Tan, Eddy,Lin, Grace,Austad, Brian C.,Yu, Lin-Chen,Behnke, Mark L.,Nair, Somarajan J.,Hagel, Margit,White, Kerry,Conley, James,Manna, Joseph D.,Alvarez-Diez, Teresa M.,Hoyt, Jennifer,Woodward, Caroline N.,Sydor, Jens R.,Pink, Melissa,MacDougall, John,Campbell, Matthew J.,Cushing, Jill,Ferguson, Jeanne,Curtis, Michael S.,McGovern, Karen,Read, Margaret A.,Palombella, Vito J.,Adams, Julian,Castro, Alfredo C.

experimental part, p. 4400 - 4418 (2010/03/02)

Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of cancer. Cyclopamine, a plant Veratrum alkaloid, is a natural product antagonist of the hedgehog pathwa

CYCLOPAMINE ANALOGS

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Page/Page column 59, (2008/12/07)

The invention provides novel derivatives of cyclopamine having the following formula.

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