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(4S)-N-[(2S,3R)-4-(3-dimethylaminophenyl)methylamino-3-hydroxy-1-phenylbutan-2-yl]-2-oxo-1-[(4-trifluoromethylphenyl)methyl]imidazolidine-4-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1037222-48-2

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1037222-48-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1037222-48-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,7,2,2 and 2 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1037222-48:
(9*1)+(8*0)+(7*3)+(6*7)+(5*2)+(4*2)+(3*2)+(2*4)+(1*8)=112
112 % 10 = 2
So 1037222-48-2 is a valid CAS Registry Number.

1037222-48-2Downstream Products

1037222-48-2Relevant academic research and scientific papers

BETA-SECRETASE INHIBITING COMPOUNDS

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Page/Page column 72, (2009/04/25)

Disclosed are compounds represented by Formula (I) as defined in the specification, or pharmaceutically acceptable salts or isomers thereof, and a pharmaceutical composition for inhibiting beta-secretase activity comprising a therapeutically effective amount of the same.

Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives

Park, Heuisul,Min, Kyeongsik,Kwak, Hyo-Shin,Koo, Ki Dong,Lim, Dongchul,Seo, Sang-Won,Choi, Jae-Ung,Platt, Bettina,Choi, Deog-Young

, p. 2900 - 2904 (2008/12/22)

We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.1

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