1037222-64-2Relevant academic research and scientific papers
Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives
Park, Heuisul,Min, Kyeongsik,Kwak, Hyo-Shin,Koo, Ki Dong,Lim, Dongchul,Seo, Sang-Won,Choi, Jae-Ung,Platt, Bettina,Choi, Deog-Young
, p. 2900 - 2904 (2008/12/22)
We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.1
