103729-96-0Relevant articles and documents
CREATION OF CHIRALITY IN THE REACTION OF THE CHIRAL ESTER ENOLATE-IMINE CONDENSATION LEADING TO THE STEREODIVERGENT SYNTHESIS OF β-LACTAMS
Shimizu, Makoto,Teramoto, Yoshihiro,Fujisawa, Tamotsu
, p. 729 - 732 (1995)
Stereocontrol at C-4 of the β-lactams possessing substituents at 3- and 4-positions in the ester enolate-imine condensation is studied using different metal enolates of the chiral esters possessing amino alcohols derived all from (+)-camphor as an auxiliary, and 4R- or 4S-β-lactam is obtained in a highly stereoselective manner, respectively.The effects of the structure of the chiral auxiliary and the coordination ability of the heteroatoms in the ester part are also dicussed.