1037307-70-2

Upstream product

• 1037307-69-9 2,2,2-trichloroethyl (2S,3S)-3-O-[5-tert-butoxycarbonylamino-5-deoxy-2,3-O-(3-pentylidene)-β-D-ribofuranosyl]-2-benzyloxycarbonylamino-3-hydroxybutanoate 

Downstream Products

• 1037307-71-3 N-[(1S,2S)-2-tert-butyldiphenylsiloxy-1-tert-butoxycarbonyl-3-butenyl]-N-methyl-2-benzyloxycarbonylamino-3-O-[5-tert-butoxycarbonylamino-5-deoxy-2,3-O-(3-pentylidene)-β-D-ribofuranosyl]-2-hydroxybutanamide 

Relevant academic research and scientific papers

Structure-activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents

Systematic structure-activity relationship studies of caprazamycin (CPZ) analogs, including the aminoribose-truncated 5 and the uridine-truncated 6, have been carried out. Both 5 and 6 were synthesized efficiently via diazepanone ring construction by intramolecular reductive alkylation of aminoaldehyde derivatives. The antibacterial activity of a range of analogs, including 5 and 6, against Mycobacteriumosis was evaluated, and it was found that the uridine, the aminoribose, and the fatty acyl side chains are crucial for antibacterial activity. This study would be a guide for designing novel anti-tuberculosis agents based on the 6′-N-alkyl-5′-β-O-aminoribosyl-glycyluridine class of antibiotics including the CPZs.