1037364-92-3

Basic information

• Product Name: 4-(1H-INDOL-5-YL)-BENZOIC ACID ETHYL ESTER
• Synonyms: 4-(1H-INDOL-5-YL)-BENZOIC ACID ETHYL ESTER;ETHYL 4-(1H-INDOL-5-YL)-BENZOATE
• CAS NO: 1037364-92-3
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.3065
• Mol File: 1037364-92-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1H-INDOL-5-YL)-BENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-INDOL-5-YL)-BENZOIC ACID ETHYL ESTER(1037364-92-3)
• EPA Substance Registry System: 4-(1H-INDOL-5-YL)-BENZOIC ACID ETHYL ESTER(1037364-92-3)

Safety Data

• Hazardous Substances Data: 1037364-92-3(Hazardous Substances Data)

Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 144104-59-6 1H-indole-5-boronic acid 

Relevant articles and documents

N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5α-reductase type I and II inhibitory activity

The synthesis of N-alkyl and N-arylalkyl substituted 4-(5- indolyl)benzoic acid derivatives as inhibitors of steroid 5α-reductases is described. For the human type II isozyme a benzyl substituent (IC50 6.20 μM) and for the human type I isozyme a cyclohexanemethyl substituent (IC50 2.10 μM) on the indole nitrogen proved to be most efficacious, thus providing interesting leads for the development of drugs for the treatment of benign prostatic hyperplasia (BPH).

Negishi cross-couplings of unsaturated halides bearing relatively acidic hydrogen atoms with organozinc reagents

(Chemical Equation Presented) A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated halides bearing an acidic NH or OH function, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups.