1037366-92-9

Upstream product

• 1037366-91-8 tert-butyl (3S)-5-oxo-1-[(1R)-1-phenylethyl]-3-(prop-2-en-1-yl)pyrrolidine-3-carboxylate 
• 915302-93-1 2-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-4-carboxylic acid tert-butyl ester 

Downstream Products

• 1037367-47-7 (3S)-3-[3-(tert-butyldimethylsilyloxy)-1-propyl]-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylic acid tert-butyl ester 
• 1037368-83-4 (3S)-3-(3-oxo-1-propyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylic acid tert-butyl ester 
• 1037367-67-1 (3S)-3-(2-methoxycarbonyl-1-ethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of novel 8-methoxyquinolones bearing fused pyrrolidinyl moieties at the C-7 position with potent antibacterial activity against respiratory pathogens

Novel 8-methoxyquinolones bearing fused pyrrolidinyl moieties at the C-7 position were designed, synthesized, and evaluated for their potent antibacterial activity for the treatment of respiratory tract infections. Compound 5, possessing a trans-fused octahydroisoindole ring at the C-7 position of the quinolone scaffold, exhibited potent in vitro antibacterial activity against nosocomial respiratory pathogens including levofloxacin-resistant Escherichia coli and methicillin-resistant Staphylococcus aureus strains. Furthermore, compound 5 showed a favorable pharmacokinetic profile after a single oral administration in rats.

FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE

A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacteria