1037411-79-2Relevant academic research and scientific papers
Discovery of selective indole-based prostaglandin D2 receptor antagonist
Iwahashi, Maki,Shimabukuro, Atsushi,Onoda, Takahiro,Matsunaga, Yoko,Okada, Yutaka,Matsumoto, Ryoji,Nambu, Fumio,Nakai, Hisao,Toda, Masaaki
, p. 4574 - 4588 (2011)
A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D2 receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure-activity relationship study is presented.
LIGANDS FOR CARDIAC BETA1 ADRENOCEPTOR FOR IMAGING CONGESTIVE HEART FAILURE
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Page/Page column 29, (2008/12/07)
Novel β1 adrenoreceptor ligands that find use as imaging agents within nuclear medicine applications (e.g., PET imaging and SPECT imaging) are provided. Methods of imaging, including methods of imaging congestive heart failure, are also provide
