1037462-26-2Relevant academic research and scientific papers
Oxidative aromatization of 1,4-dihydropyridines and pyrazolines using HbA-H2O2: An efficient biomimetic catalyst system providing metabolites of drug candidates
Kumar, Atul,Maurya, Ram Awatar,Sharma, Siddharth
scheme or table, p. 4432 - 4436 (2010/04/05)
Human hemoglobin (HbA) efficiently catalyses the oxidative aromatization of 1,4-dihydropyridines (1,4-DHPs) and pyrazolines with hydrogen peroxide in phosphate buffer. The results of the study reveal that the rates of oxidative aromatization of 1,4-DHPs a
An efficient, metal-free, room temperature aromatization of Hantzsch-1,4-dihydropyridines with urea-hydrogen peroxide adduct, catalyzed by molecular iodine
Filipan-Litvi?, Mirela,Litvi?, Mladen,Vinkovi?, Vladimir
, p. 5649 - 5656 (2008/09/21)
A mild, highly efficient and metal-free synthetic method for aromatization of 1,4-dihydropyridines employing urea-hydrogen peroxide adduct as oxidant catalyzed by 20 mol % of molecular iodine was developed. The reaction was carried out in ethyl acetate at room temperature and the products were isolated in high to excellent yields. A plausible free-radical mechanism is proposed based on results obtained with derivatives having alkyl and aryl substituents in the 1,4-dihydropyridine ring.
A highly efficient biomimetic aromatization of Hantzsch-1,4-dihydropyridines with t-butylhydroperoxide, catalysed by iron(III) phthalocyanine chloride
Filipan-Litvic, Mirela,Litvic, Mladen,Vinkovic, Vladimir
experimental part, p. 9276 - 9282 (2009/04/05)
Rapid aromatization of Hantzsch-1,4-DHPs with t-butylhydroperoxide catalysed by iron(III) phthalocyanine chloride is described. The reaction proceeds smoothly at room temperature within 1-35 min and the products of high purity were isolated in excellent yields. To explain the reactivity of this catalytical system plausible mechanism have been proposed to involve formation of high-valent oxoferryl species as in cytochrome P450 itself.
