1037510-76-1Relevant articles and documents
Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors
Fang, Kun,Dong, Guoqiang,Li, Yu,He, Shipeng,Wu, Ying,Wu, Shanchao,Wang, Wei,Sheng, Chunquan
, p. 312 - 317 (2018)
In order to take advantage of both immunotherapeutic and epigenetic antitumor agents, the first generation of dual indoleamine 2,3-dioxygenase 1 (IDO1) and histone deacetylase (HDAC) inhibitors were designed. The highly active dual inhibitor 10 showed exc
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry
Colombano, Giampiero,Travelli, Cristina,Galli, Ubaldina,Caldarelli, Antonio,Chini, Maria Giovanna,Canonico, Pier Luigi,Sorba, Giovanni,Bifulco, Giuseppe,Tron, Gian Cesare,Genazzani, Armando A.
supporting information; experimental part, p. 616 - 623 (2010/07/06)
The inhibition of NAD synthesis or salvage pathways has been proposed as a novel target for antitumoral drugs. Two molecules with this mechanism of action are at present undergoing clinical trials. In searching for similar novel molecules, we exploited co