1037511-49-1

Basic information

• Product Name: methyl 5-(4-benzyl-1H-1,2,3-triazol-1-yl)hexanoate
• Synonyms: methyl 5-(4-benzyl-1H-1,2,3-triazol-1-yl)hexanoate
• CAS NO: 1037511-49-1
• Molecular Weight: 273.335
• Mol File: 1037511-49-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 5-(4-benzyl-1H-1,2,3-triazol-1-yl)hexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-(4-benzyl-1H-1,2,3-triazol-1-yl)hexanoate(1037511-49-1)
• EPA Substance Registry System: methyl 5-(4-benzyl-1H-1,2,3-triazol-1-yl)hexanoate(1037511-49-1)

Safety Data

• Hazardous Substances Data: 1037511-49-1(Hazardous Substances Data)

Upstream product

• 10147-11-2 propargyl benzene 
• 127811-93-2 5-azidovaleric acid methyl ester 

Downstream Products

• 1037511-80-0 C₁₄H₁₈N₄O₂ 

Relevant articles and documents

Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group

Histone deacetylase (HDAC) inhibition is a recent, clinically validated therapeutic strategy for cancer treatment. Small molecule HDAC inhibitors identified so far fall in to three distinct structural motifs: the zinc-binding group (ZBG), a hydrophobic linker, and a recognition cap group. Here we report the suitability of a 1,2,3-triazole ring as a surface recognition cap group-linking moiety in suberoylanilide hydroxamic acid-like (SAHA-like) HDAC inhibitors. Using "click" chemistry (Huisgen cycloaddition reaction), several triazole-linked SAHA-like hydroxamates were synthesized. Structure-activity relationship revealed that the position of the triazole moiety as well as the identity of the cap group markedly affected the in vitro HDAC inhibition and cell growth inhibitory activities of this class of compounds.