103754-13-8

Upstream product

• 64-17-5 ethanol 
• 1529-41-5 3-chloro-benzeneacetonitrile 

Downstream Products

• 142590-58-7 2-(3-Chloro-benzyl)-3H-imidazo[4,5-b]pyridine 
• 877315-77-0 ethyl m-chlorophenylacetate ethoxycarbonyl hydrazone 
• 877315-81-6 3-m-chlorobenzyl-4-amino-4,5-dihydro-1H-1,2,4-triazole-5-one 
• 1273315-64-2 2-(3-chlorobenzyl)-9-methyl-7,9-dihydro-8H-purine-8-one 
• 1273315-60-8 ethyl 2-(3-chlorobenzyl)-4-(methylamino)pyrimidine-5-carboxylate 
• 1273315-62-0 2-(3-chlorobenzyl)-4-(methylamino)pyrimidine-5-carboxylate 
• 6487-96-3 2-(3-chlorophenyl)ethaneimidamide hydrochloric acid salt 
• 1450838-38-6 phenyl[2-(3-chlorobenzyl)-1H-1,3-benzimidazol-5-yl]methanone 
• 1443550-86-4 methyl 2-[5,6-dichloro-2-(3-chlorobenzyl)-1H-benzimidazol-1-yl]acetate 
• 1443550-92-2 2-[5,6-dichloro-2-(3-chlorobenzyl)-1H-benzimidazol-1-yl]acetic acid hydrazide 
• 1443550-81-9 5,6-dichloro-2-(3-chlorobenzyl)-1H-benzimidazole 
• 1470364-74-9 5-(m-chlorobenzyl)-4-p-fluorobenzyliden amino-2,4-dihydro-2H-1,2,4-triazol-3-one 
• 1470364-75-0 5-(m-chlorobenzyl)-4-p-nitrobenzyliden amino-2,4-dihydro-2H-1,2,4-triazol-3-one 
• 1616422-67-3 N-[2-(3-chlorobenzyl)-4-phenyl-1H-imidazol-1-yl]-2-phenylacetamide 

Relevant academic research and scientific papers

Synthesis of Some Novel 2-Substitutedbenzyl-(4)7-phenyl-1H-benzo[d]imidazoles in Mild Conditions as Potent Anti-Tyrosinase and Antioxidant Agents

Novel 2-substitutedbenzyl-4(7)-phenyl-1H-benzo[d]imidazole compounds were synthesized and characterized. Although 2a and 2b were reported previously in the literature, 11 compounds were synthesized (nine of them were newly synthesized) and the tyrosinase inhibitory effects and antioxidant activities of these compounds were studied for the first time. All of the synthesized compounds displayed certain inhibitory effects on tyrosinase, with IC50 values ranging from 37.86 ± 0.24 to 75.81 ± 2.49 μM. Among the compounds, 2j exhibited similar tyrosinase inhibitory effect (IC50 = 37.86 ± 0.24 μM) to the positive control, kojic acid (IC50 = 21.93 ± 0.11 μM). Kinetic studies revealed it to act as non-competitive tyrosinase inhibitor with a Ki value of 50.2 μM. The antioxidant activities of the compounds were investigated by using in vitro antioxidant assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). All of these results indicated that the compounds might have potential application as tyrosinase inhibitors.

Efficient microwave assisted synthesis of some new benzimidazoles containing the mebendazole nucleus

A simple and practical method has been developed for the synthesis of benzimidazoles containing the biological active mebendazole nucleus. Iminoester hydrochlorides of phenylacetic acids were used as intermediates in the reaction with 3,4-diaminobenzophen

Microwave-assisted synthesis of some 5(6)-nitro-1H-benzimidazoles and their hydrazide derivatives

A series of 5(6)-nitro-1H-benzimidazole and their hydrazide derivatives were synthesized starting from iminoester hydrochloride and 4-nitro-o- phenylenediamine under microwave irradiation. The structure of all synthesized compounds was confirmed by IR, s

8-OXODIHYDROPURINE DERIVATIVE

The present invention provides a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof (wherein W represents a hydrogen atom, a halogen atom, or the others; A represents an alkyl group optionally substituted by aryl group or the others, an aryl group, or the others; and one of X and Y represents a di-substituted alkylaminocarbonyl group, or the others, and the other represents a hydrogen atom, an alkyl group, an alkylcarbonyl group, or the others); a medicament or a pharmaceutical composition for treatment or prophylaxis of FAAH-related diseases such as depression, anxiety disorder or pains, comprising the compound or the like as an active ingredient; a use of the compound or the like; and a method for treatment or prophylaxis using the compound or the like.

Microwave-assisted synthesis of some new benzylidenamino compounds and potentiometric determination of their pKa

A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new benzylidenamino compounds (4a-f) via microwave heating using a m

Synthesis of 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their isatin-3-imine derivatives

Iminoester hydrochlorides 1 have been synthesized. These compounds were then converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new series of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared. Finally a set

Synthesis and cytotoxicity of substituted 2-benzylnaphth[2,3-d]imidazoles

Designed as a new series of so called "bivalent ligand" containing the proposed 2-benzylnaphthimidazole-type structure, a number of 2-benzylnaphth[2,3-d]imidazoles, bearing various substituents, have been prepared by a synthetic approach involving an hete