1037575-84-0Relevant academic research and scientific papers
Gamma-lactams-A novel scaffold for highly potent and selective α7 nicotinic acetylcholine receptor agonists
Enz, Albert,Feuerbach, Dominik,Frederiksen, Mathias U.,Gentsch, Conrad,Hurth, Konstanze,Mueller, Werner,Nozulak, Joachim,Roy, Bernard L.
scheme or table, p. 1287 - 1291 (2009/10/02)
A novel class of α7 nicotinic acetylcholine receptor (nAChR) agonists has been discovered through high-throughput screening. The cis γ-lactam scaffold has been optimized to reveal highly potent and selective α7 nAChR agonists with in vitro activity and selectivity and with good brain penetration in mice.
