1037578-53-2Relevant academic research and scientific papers
A convenient asymmetric synthesis of the octalactin lactone
Sharma, Anubha,Gamre, Sunita,Roy, Siddharth,Goswami, Dibakar,Chattopadhyay, Angshuman,Chattopadhyay, Subrata
, p. 3902 - 3905 (2008/09/21)
A facile asymmetric synthesis of the octalactin lactone was developed staring from (R)-cyclohexylideneglyceraldehyde (1). The key step of the synthesis is an In-mediated diastereoselective crotylation of 1 in water, which furnished the building blocks with the required stereochemistry under operationally simple conditions. Their conversion to the appropriate intermediates, invertive esterification and a ring closing metathesis reaction furnished the target compound.
