1037585-99-1Relevant academic research and scientific papers
Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate
Posner, Gary H.,Maio, William A.,Kalinda, Alvin S.
, p. 5247 - 5253 (2008/12/20)
From 9-substituted DHA, several new artemisinin-derived C-10 acetal ethers and esters were prepared with either a 9-fluoro or a 9-sulfonyl substituent. The very strong inductive electron-withdrawing C-9 substituent is shown to retard considerably C-10 ionization (acid-promoted etherification) of 9-fluoro-DHA and 9-sulfonyl-DHA.
