1037590-17-2Relevant academic research and scientific papers
Isothiourea-mediated one-pot synthesis of trifluoromethyl substituted 2-pyrones
Yeh, Pei-Pei,Daniels, David S. B.,Cordes, David B.,Slawin, Alexandra M. Z.,Smith, Andrew D.
, p. 964 - 967 (2014/03/21)
A one-pot isothiourea-mediated Michael addition/lactonization/thiol elimination cascade sequence for the formation of 4,6-disubstituted and 3,4,6-trisubstituted 2-pyrones from (phenylthio)acetic acids and α,β-unsaturated trifluoromethyl ketones is described. The synthesis of a COX-2 inhibitor and the wide-ranging derivatization of the 2-pyrone moiety to trifluoromethyl substituted aromatics and heteroaromatics is also disclosed.
Synthesis of 3-(trifluoromethyl)indeno[2,1-c]pyran-1,9-diones from 4-aryl-3-carbethoxy-6-(trifluoromethyl)-2-pyrones and their reaction with sodium azide leading to new carbostyril derivatives
Usachev, Sergey A.,Usachev, Boris I.,Sosnovskikh, Vyacheslav Ya.
, p. 60 - 66 (2014/01/06)
Treatment of ethyl 4-aryl-6-(trifluoromethyl)-2-oxo-2H-pyran-3- carboxylates, prepared from 4,4,4-trifluorobutane-1,3-diones, PCl5 and sodium diethyl malonate, with sulfuric acid afforded the intramolecular Friedel-Crafts acylation products, 3-
Convenient synthesis of ethyl 4-aryl-6-(trifluoromethyl)-2-oxo-2H-pyran-3- carboxylates and 4-aryl-6-(trifluoromethyl)-2H-pyran-2-ones: Novel highly reactive CF3-containing building blocks
Usachev, Boris I.,Obydennov, Dmitrii L.,Roeschenthaler, Gerd-Volker,Sosnovskikh, Vyacheslav Ya.
scheme or table, p. 2857 - 2859 (2009/05/27)
(Chemical Equation Presented) An expedient synthesis of a series of 2-pyrones, bearing a CF3 group at the 6-position and aryl group at position 4, from readily available aryl-4,4,4-trifluorobutane-1,3-diones, PCl5, and sodium diethyl malonate is described.
