1037593-41-1Relevant academic research and scientific papers
Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors
Wang, Qiang,Chen, Maoying,Zhu, Huawei,Zhang, Jie,Fang, Hao,Wang, Binghe,Xu, Wenfang
, p. 5473 - 5481 (2008/12/21)
A series of novel l-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N (APN)/CD13 and matrix metalloproteinase-2 (MMP-2). The preliminary biological test showed that most of the compounds displayed a high inhibitory activity against MMP-2 and a low activity against APN except compound B6 which exhibited good potency (IC50 = 13.2 μM) similar with APN inhibitor Bestatin (IC50=15.5 μM), and could be used as lead compound in the future.
