1037597-71-9Relevant academic research and scientific papers
Direct Arylation of Azoles Enabled by Pd/Cu Dual Catalysis
Piou, Tiffany,Slutskyy, Yuriy,Kevin, Nancy J.,Sun, Zhongxiang,Xiao, Dong,Kong, Jongrock
, p. 1996 - 2001 (2021)
A practical approach toward the synthesis of 2-arylazoles via direct arylation is described. The transformation relies on a Pd/Cu cocatalyst system that operates with low catalyst loadings. The reaction conditions were found to be tolerant of a wide range of functional groups and nitrogen-containing heterocycles commonly employed in a drug discovery setting.
Palladium-catalyzed direct C2-arylation of azoles with aromatic triazenes
Liu, Can,Wang, Zhiming,Wang, Lei,Li, Pinhua,Zhang, Yicheng
, p. 9209 - 9216 (2019/11/05)
A highly efficient palladium-catalyzed arylation of azoles at the C2-position using 1-aryltriazenes as aryl reagents was developed. Azoles including oxazoles, thiazoles, imidazoles, 1,3,4-oxadiazoles, and oxazolines could react with 1-aryltriazenes smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.
Palladium-catalyzed deamidative arylation of azoles with arylamides through a tandem decarbonylation-C-H functionalization
Li, Chengliang,Li, Pinhua,Yang, Jin,Wang, Lei
supporting information; experimental part, p. 4214 - 4216 (2012/05/04)
A highly chemo-, regio-selective, and efficient palladium-catalyzed deamidative arylation of azoles with arylamides, as an aryl metal equivalent, has been developed. The reaction proceeds smoothly to generate the corresponding products in good yields via a tandem decarbonylation-C-H activation.
